Von Willebrand Disease Treatment – Orthodox Medicine

von Willebrand disease Treatment (VWD) is based on the type of VWD and the severity of symptoms.

The aim of therapy is to correct the acquired clotting problem. This is mostly and usually accomplished by raising the levels of VWF (von Willebrand factor) and factor VIII (another protein in the bloodstream).

Most cases of VWD are mild, so you may need treatment only if you have planned or abnormal conditions such as minor surgery procedures, tooth extractions, or after an accident.

If your condition does require treatment, there are several options and medicaments available.

DDAVP® {Desmopressin acetate} Injection

This medicine is nothing but a modified synthetic copy of vasopressin (a natural hormone), which works by assisting the body to release stored VWF into the bloodstream side by side by increasing the levels of factor VIII.

Side effects may include:

-local injection (site reactions),

-facial flushing,

-headache

-changes in blood pressure.

It is mostly given to patients as an infusion (by means of injection into a vein), but it can also be given subcutaneously (injected under the skin).

Stimate® (Desmopressin acetate) Nasal Spray 1.5 mg/ml

Stimate® (Desmopressin acetate) in the form of Nasal Spray 1.5 mg/ml is another type of Desmopressin, made as a high concentrate nasal spray.

Plusses:

– It can be used easily without the need of help like injections.

Stimate usage is recommended for people with mild or moderate Type 1 VWD.

Common side effects:

-facial flushing

-headache

Note that Desmopressin nasal spray is fabricated in two forms:

-low concentrate

-high concentrate

Low concentrate nasal spray is used to treat:

– diabetes insipidus

-bed wetting diseases

High concentrate nasal spray is aimed for von Willebrand disease Treatment

Factor replacement therapies – Factor Concentrates

Factor replacement therapies are medicaments given to replace the missing VWF in patients with VWD.

There are two kinds of replacement therapy:

-factor concentrates containing VWF, (preferred for von Willebrand disease Treatment because they are treated to kill any possible viral infection)

-cryoprecipitate.

Both Factor Concentrates are derived from fresh plasma and are set to be given by infusion.

Humate-P®

Humate-P® the Antihemophilic Factor/von Willebrand Factor Complex (Human). Is the only VWF concentrate approved in the United States for von Willebrand disease Treatment (it is used for all types of von Willebrand disease),

Humate-P is effective for most if not all bleeding episodes in all types of von Willebrand disease.

Usage:

-Humate-P is taken by injection. (Home infusion).

Antifibrinolytics (Local clotting agents)

Typical local clotting agents, or antifibrinolytics, usually taken as an injection or via oral tract (by mouth) (tablet, capsule, mouthwash or elixir).

Role:

They help protect clots and hold them in place (anti burst action) thus they help evacuate the reasons of thrombosis i.e. they decrease the possibilities of brain insults, heart attacks…

Usage:

antifibrinolytics can be used to stop bleeding in many circumstances and specially those related to digestive system problems, bleedings from mouth, nose, or gastrointestinal tract.

They are highly used to help control heavy bleeding during the menstrual period.

Oral contraceptive pills (Birth control pills)

OCP, Birth control pills, or oral contraceptives, can increase the levels of VWF, by affecting the glandular system as a whole, side by side by affecting the tonus of the white muscles and their mighty role in powering the immune system and fighting hypertension, though they increase the risk of clotting, and is not favored in women with hypotension or thrombolytic diseases

Oral contraceptive pills should be used with the supervision of a doctor specially when it is taken for von Willebrand disease Treatment.

Oral contraceptives are very useful for women with HMB syndrome (heavy menstrual bleeding syndrome).